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), which is identical angular place as the covalent connections among the ChVLig OB area plus the strands in the latch. Thus, Character has identified very diverse structural solutions to the issue of DNA envelopment by ATP-dependent ligases.
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(18) Sports Betting Online have performed a Digital screen for tiny molecules that can dock to the N-terminal DBD of HuLig1, a domain conserved in all mammalian DNA ligases. They thereby discovered compounds that (i) inhibited nick sealing by human ligases in vitro
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